Single dosis vaksin Ebola aman , efektif pada monyet terhadap wabah /outbreak strain--T-REC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

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Single  dosis vaksin Ebola aman , efektif pada  monyet terhadap wabah /outbreak strain

Date:

August 6, 2015

Source:

NIH/National Institute of Allergy and Infectious Diseases

Summary:

Sebuah dosis tunggal vaksin virus Ebola eksperimental sepenuhnya melindungi kera cynomolgus melawan arus ketegangan wabah EBOV  , EBOV - Makona , ketika diberikan setidaknya tujuh hari sebelum paparan , dan sebagian melindungi mereka jika diberikan tiga hari sebelumnya, laporan ilmuwan . vaksin Hidup - dilemahka , VSV - EBOV , menggunakan rekayasa genetika virus vesikular stomatitis untuk membawa gen EBOV yang aman diinduksi kekebalan protektif di kera 

......... Sebelum penelitian ini , para ilmuwan tidak memiliki informasi tentang bagaimana monyet divaksinasi dengan VSV - EBOV akan menanggapi tantangan dengan EBOV - Makona , yang telah menyebar ke seluruh Afrika Barat ........more

Single dose
Ebola vaccine is safe, effective in monkeys against outbreak strain

VSV-EBOV appears to trigger innate, adaptive immunity

Date:

August 6, 2015

Source:

NIH/National Institute of Allergy and Infectious Diseases

Summary:

A single dose of an experimental Ebola virus vaccine completely protects
cynomolgus macaques against the current EBOV outbreak strain, EBOV-Makona, when
given at least seven days before exposure, and partially protects them if given
three days prior, scientists report. The live-attenuated vaccine, VSV-EBOV,
uses genetically engineered vesicular stomatitis virus to carry an EBOV gene
that has safely induced protective immunity in macaques.

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National Institutes of Health (NIH) scientists report that a single dose of
an experimental Ebola virus (EBOV) vaccine completely protects cynomolgus
macaques against the current EBOV outbreak strain, EBOV-Makona, when given at
least seven days before exposure, and partially protects them if given three
days prior. The live-attenuated vaccine, VSV-EBOV, uses genetically engineered
vesicular stomatitis virus (VSV) to carry an EBOV gene that has safely induced
protective immunity in macaques. The experimental vaccine is currently
undergoing testing in a global clinical trial in humans. VSV, an animal virus
that primarily affects cattle, has been successfully tested as an experimental
vaccine platform against several viruses.

Prior to this study, scientists had no information about how monkeys
vaccinated with VSV-EBOV would respond to a challenge with EBOV-Makona, which
has spread throughout West Africa. Previous animal studies demonstrated that
VSV-EBOV could successfully protect monkeys against the first EBOV strain
recognized, Mayinga, in 1976, and against EBOV-Kikwit, a strain that emerged in
Central Africa in 1995. This new study shows that certain immune responses
induced by VSV-EBOV are similar against all three viruses. The scientists, from
NIH's National Institute of Allergy and Infectious Diseases Division of
Intramural Research, concluded from these findings that VSV-EBOV likely would
be equally protective against different EBOV strains.

The group also observed that the experimental VSV-EBOV vaccine appears to
provide initial protection by triggering innate virus-fighting host responses;
these responses partially protected animals challenged with EBOV-Makona within
a week after vaccination. Animals vaccinated more than a week before viral
challenge developed antibodies, an adaptive immune response, that were shown to
be critical for protection.







Story Source:

The above post is reprinted from materials provided byNIH/National
Institute of Allergy and Infectious Diseases.Note: Materials
may be edited for content and length.







Journal Reference:

1.   
A Marzi et al. VSV-EBOV rapidly protects macaques against infection
with the 2014/15 Ebola virus outbreak strain. Science, August
2015 DOI:10.1126/science.aab3920

http://www.sciencedaily.com/releases/2015/08/150806151403.htm

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