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Sel pintar mengajari  neuron yang  rusak oleh Parkinson untuk menyembuhkan diri sendiri

Para ilmuwan menciptakan sel-sel darah putih yang mengajarkan sel-sel otak untuk menyembuhkan kerusakan yang disebabkan oleh gangguan saraf degeneratif seperti penyakit Parkinson

Date:

September 11, 2015

Source:

University of North Carolina at Chapel Hill

Summary:

Sebagai pengobatan yang potensial untuk penyakit Parkinson , para ilmuwan telah menciptakan sel-sel kekebalan cerdas yang memproduksi dan memberikan protein penyembuhan ke otak sementara juga mengajar neuron untuk mulai membuat protein untuk diri mereka sendiri .

.......... Para peneliti , dipimpin oleh Elena Batrakova , seorang profesor di UNC ESHELMAN Sekolah Farmasi Pusat untuk Nanoteknologi di Drug delivery  , yang dimodifikasi secara genetik sel-sel darah putih yang disebut makrofag untuk memproduksi sel- glial berasal dari faktor neurotropik , atau GDNF , dan mengirimkannya ke otak ....more

Smart cells teach neurons damaged by Parkinson's to
heal themselves

Scientists creating white blood cells
that teach brain cells to heal damage caused by degenerative neurological
disorders like Parkinson's disease

Date:

September 11, 2015

Source:

University of North Carolina at Chapel
Hill

Summary:

As a potential treatment for Parkinson's
disease, scientists have created smarter immune cells that produce and deliver
a healing protein to the brain while also teaching neurons to begin making the protein
for themselves.

................

As a potential treatment for Parkinson's
disease, scientists at the University of North Carolina at Chapel Hill have
created smarter immune cells that produce and deliver a healing protein to the
brain while also teaching neurons to begin making the protein for themselves.

The researchers, led by Elena Batrakova,
an associate professor at the UNC Eshelman School of Pharmacy's Center for
Nanotechnology in Drug Delivery, genetically modified white blood cells called
macrophages to produce glial cell-derived neurotrophic factor, or GDNF, and
deliver it to the brain. Glial cells provide support and protection for nerve
cells throughout the brain and body, and GDNF can heal and stimulate the growth
of damaged neurons.

"Currently, there are no treatments
that can halt or reverse the course of Parkinson's disease. There are only
therapies to address quality of life, such as dopamine replacement,"
Batrakova said. "However, studies have shown that delivering neurotrophic
factor to the brain not only promotes the survival of neurons but also reverses
the progression of Parkinson's disease."

In addition to delivering GDNF, the
engineered macrophages can "teach" neurons to make the protein for
themselves by delivering both the tools and the instructions needed: DNA,
messenger RNA and transcription factor.

Successfully delivering the treatment to
the brain is the key to the success of GDNF therapy, said Batrakova. Using
immune cells avoids the body's natural defenses. The repurposed macrophages are
also able to penetrate the blood-brain barrier, something most medicines cannot
do. The reprogrammed cells travel to the brain and produce tiny bubbles called
exosomes that contain GDNF. The cells release the exosomes, which then are able
to deliver the proteins to neurons in the brain. The work is described in an
article published online by PLOS ONE.

"By teaching immune system cells to
make this protective protein, we harness the natural systems of the body to
combat degenerative conditions like Parkinson's disease," Batrakova said.

The North Carolina Biotechnology Center
awarded a $50,000 Technology Enhancement Grant to the School to help develop
the technology into a viable treatment that can be licensed and commercialized.

"This award is an enormously
important step towards further successful commercialization of our very
exciting cell technologies," said Alexander Kabanov, director of the
nanotechnology center. "We will continue our translational efforts at
CNDD, and very soon I believe we will see these discoveries on the frontiers of
scientific moving into clinical practice."







Story Source:

The above post is reprinted from materials provided byUniversity
of North Carolina at Chapel Hill. Note:
Materials may be edited for content and length.







Journal Reference:

1.   
Yuling Zhao, Matthew J. Haney, Richa
Gupta, John P. Bohnsack, Zhijian He, Alexander V. Kabanov, Elena V.
Batrakova. GDNF-Transfected Macrophages Produce Potent Neuroprotective
Effects in Parkinson's Disease Mouse Model. PLoS ONE, 2014; 9
(9): e106867 DOI: 10.1371/journal.pone.0106867

http://www.sciencedaily.com/releases/2015/09/150911112710.htm

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