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Bakteri perut Anda menentukan diet yang terbaik untuk penurunan berat badan

Date:

September 10, 2015

Source:

Chalmers University of Technology

Summary:

New research enables "tailored" diet advice -- based on our personal gut microbiome -- for persons who want to lose weight and reduce the risk of disease. Systems biologists have, for the first time, successfully identified in detail how some of our most common intestinal bacteria interact during metabolism.

Penelitian baru telah memungkinkan " penyesuaian " saran diet - berdasarkan  microbiome usus  pribadi kita - untuk orang yang ingin menurunkan berat badan dan mengurangi risiko penyakit . ahli biologi telah menemukan system  , untuk pertama kalinya , berhasil mengidentifikasi secara detail bagaimana beberapa bakteri usus kita yang paling umum berinteraksi selama metabolisme 

............. The researchers at Chalmers University of Technology have developed a mathematical calculation platform that makes it possible to predict how different patients will respond to a modified diet, depending on how their gut microbiome is composed.

.......... Para peneliti di Chalmers University of Technology telah mengembangkan sebuah platform perhitungan matematika yang memungkinkan untuk memprediksi bagaimana pasien yang berbeda akan merespon diet dimodifikasi , tergantung pada bagaimana microbiome usus mereka .....more

Your stomach bacteria determines which diet is best
for weight reduction

Date:

September 10, 2015

Source:

Chalmers University of Technology

Summary:

New research enables
"tailored" diet advice -- based on our personal gut microbiome -- for
persons who want to lose weight and reduce the risk of disease. Systems
biologists have, for the first time, successfully identified in detail how some
of our most common intestinal bacteria interact during metabolism.

...............

New research enables
"tailored" diet advice -- based on our personal gut microbiome -- for
persons who want to lose weight and reduce the risk of disease. Systems
biologists at Chalmers University of Technology have for the first time
successfully identified in detail how some of our most common intestinal
bacteria interact during metabolism.

The researchers at Chalmers University
of Technology have developed a mathematical calculation platform that makes it
possible to predict how different patients will respond to a modified diet,
depending on how their gut microbiome is composed.

Work has been conducted in cooperation
in the context of the EU funded project Metacardis, coordinated by
professor Karine Clement at Institute of Cardiometabolism and Nutrition (Ican,
Pitié-Salpêtrière Hospital, Inserm/Sorbonne University) in Paris and also
includes professor Fredrik Bäckhed at the University of Gothenburg.

"This method allows us to begin
identifying each individual bacteria type's metabolism and thus get a handle on
the basic mechanisms in human metabolism," says Jens Nielsen, professor of
systems biology at Chalmers and head of the research team.

There can be up to 1,000 different types
of bacteria and other microorganisms in the human digestive system, many of
which take part in metabolism in one way or another. The composition of the
human gut microbiome greatly varies between individuals, for reasons that are
largely unknown. However, research over the past few years has shown that there
is a connection between some diseases and the composition of the gut
microbiome.

"This is clear as regards type 2
diabetes, hardening of the arteries and obesity, for example. There are also
indications that the same might apply to depression and the body's ability to
respond to various cancer treatments," says Jens Nielsen.

Exactly how microorganisms interact with
food, the individual and not least each other is extremely complex. Until now
it has been very difficult to gain understanding of what the causal links are.
In a study that was recently published in Cell Metabolism, however,
researchers prove, through clinical trials, that the mathematical modelling
they developed works.

The point of departure is a diet
experiment that was performed at Ican. First the gut microbiome was
characterised for individuals in a group of overweight patients, and then they
were put on a weight loss diet. Everyone lost weight, which was expected. In
patients with low-diversity gut microbiome, however, the content of several
substances that generally indicate health risks was also reduced in the
individuals' blood and faeces. This was a deviation from the patients who had
gut microbiome with greater "biological diversity." Their health
situation was not affected to the same extent.

Of real interest, however, is that the
systems biologists from Chalmers with their modelling tools have largely been
able to explain why both patient groups reacted as they did to the diet.

"Amongst other things, we have been
able to demonstrate that the intestines of the individuals with low-diversity gut
microbiome produce fewer amino acids when they follow this diet. This is one
explanation for the improved blood chemistry.

In the short term, Jens Nielsen believes
the research will make it easier for physicians to identify overweight patients
who are at higher risk of cardiometabolic disease and could truly achieve major
health benefits by modifying their diet and losing weight. Fairly soon it
should be possible to design diet recommendations that take the gut microbiome
of individual patients into account. Karine Clement is already thinking along
these lines and new follow up clinical experiments are being designed.

"In the long term we might be able
to add intestinal bacteria for patients whose metabolism does not function
properly," she explains.

What are known as probiotics are already
being used -- various yoghurt cultures are one example -- but the task of these
bacteria is primarily to stabilise the intestines and create a favourable
environment.

"The next generation of probiotics
will pertain more to adding bacteria that integrate directly with the existing
gut microbiome and make a lasting change to the composition," says Jens
Nielsen.

The company Metabogen was founded based
on collaboration between researchers at Chalmers and the University of Gothenburg
and it will aim to develop these types of drugs.







Story Source:

The above post is reprinted from materials provided byChalmers
University of Technology. Note:
Materials may be edited for content and length.







Journal Reference:

1.   
Saeed Shoaie, Pouyan Ghaffari, Petia Kovatcheva-Datchary,
Adil Mardinoglu, Partho Sen, Estelle Pujos-Guillot, Tomas de Wouters,
Catherine Juste, Salwa Rizkalla, Julien Chilloux, Lesley Hoyles, Jeremy K.
Nicholson, Joel Dore, Marc E. Dumas, Karine Clement, Fredrik Bäckhed, Jens
Nielsen. Quantifying Diet-Induced Metabolic Changes of the Human Gut
Microbiome. Cell Metabolism, 2015; 22 (2): 320 DOI: 10.1016/j.cmet.2015.07.001

http://www.sciencedaily.com/releases/2015/09/150910091400.htm

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