Target pengobatan kanker : strategi ganda baru untuk menghentikan pembelahan sel--T-REC-komunitas reptil-semarang--KSE-komunitas satwa eksotik-kanker-kanker ovarium-berita artikel tentang kanker dan kanker ovarium

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Target pengobatan kanker : strategi ganda baru untuk  menghentikan pembelahan sel

Date:

September 29, 2015

Source:

Medical University of Vienna

Summary:

Sebuah tim peneliti telah dikonfirmasi dalam sebuah studi baru-baru konsep baru untuk pengobatan yang ditargetkan pada kanker ovarium . Konsep ini dimaksudkan untuk lebih mengontrol perkembangan resistensi dan peningkatkan hasil pengobatan . Strategi ini berfokus pada menghentikan pertumbuhan tumor dengan menghambat dua jaringan sinyal , bukan hanya satu . Hasilnya sangat menjanjikan ; tahap berikutnya melibatkan verifikasi konsep di in vivo studi .

............target  Pengobatan kanker  dirancang untuk memblokir jaringan sinyal yang digunakan oleh sel-sel tumor . dengan menghentikan  sel-sel ganas dari penerimaan  sinyal yang menyebabkan , misalnya, untuk pertumbuhan sel atau kematian sel ...more

Targeted cancer
treatment: New dual strategy halts cell division

Date:

September 29, 2015

Source:

Medical University of Vienna

Summary:

A team of researchers has confirmed in a recent study its new concept for
the targeted treatment of ovarian cancer. The concept is intended to better
control the development of resistance and improve treatment outcomes. The
strategy focuses on halting tumor growth by inhibiting two signal networks
instead of just one. The results are extremely promising; the next stage involves
the verification of the concept in in vivo studies.

.....................

A team of researchers at the MedUni Vienna has confirmed in a recent study
its new concept for the targeted treatment of ovarian cancer. The concept is
intended to better control the development of resistance and improve treatment
outcomes. The strategy focuses on halting tumour growth by inhibiting two
signal networks instead of just one. The results are extremely promising and
were presented at the ECC2015, which was held from the 25th to the 29th of
September in Vienna. The next stage involves the verification of the concept in
in vivo studies.

Targeted cancer treatment is designed to block the signalling networks used
by tumour cells. This stops the malignant cells from receiving signals which
lead, for example, to cell growth or cell death. Usually the structures
involved are proteins, known as receptors, which are found in abundant numbers
on the surface of the tumour cells or inside it and which pick up these signals
and pass them on, ultimately causing degeneration of the cell.

Until now, the primary focus for treatment was the cell division signalling
pathways, i.e. the mechanisms that prompt the cell to divide and grow. Thomas
Grunt from the University Department of Internal Medicine I, Head of the CCC
Research Cluster Cell Signaling and Metabolism and leader of the new study,
says: "Unfortunately, malignant cells are very flexible and develop
resistances to the new, targeted therapeutic agents we use. This is the biggest
problem in oncology. Our idea was therefore to block a second signalling system
in order to improve the impact of the substance being used."

One such network involves metabolic pathways, for example. They are also
responsible for the establishment of the cell structure, energy gain and cell
nutrition. Since malignant cells have a hyperactive fatty acid metabolism, the
team of researchers took a closer look at this in their current study. Says
Grunt: "We investigated how the two signalling pathways interact with each
other at molecular level and we were able to identify an enzyme known as
PI3K-mTORC1 kinase as the central interface for both systems. Cell tests have
shown that inhibiting this enzyme leads to cell death and reduces the rate of
cell division."

The next step is to organise further studies designed to test which of the
substances that are already available for inhibiting PI3K-mTORC1 also work in
humans. The study is being presented at the ECC2015 as part of the
translational research poster session.







Story Source:

The above post is reprinted from materials provided
by Medical University of Vienna. Note:
Materials may be edited for content and length.

http://www.sciencedaily.com/releases/2015/09/150929070230.htm

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