Bisakah maple syrup membantu mengurangi penggunaan antibiotik ?--T-REC-komunitas reptil-semarang--KSE-komunitas satwa eksotik

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Bisakah  maple syrup membantu mengurangi penggunaan antibiotik ?

Sebuah ekstrak terkonsentrasi sirup maple membuat bakteri penyebab penyakit lebih rentan terhadap antibiotik , menurut percobaan laboratorium . Temuan menunjukkan bahwa menggabungkan ekstrak maple  sirup dengan antibiotik umum dapat meningkatkan kerentanan mikroba ' , yang mengarah untuk menurunkan penggunaan antibiotik ...read more

Could maple
syrup help cut use of antibiotics?

Date:

April 16, 2015

Source:

McGill University

Summary:

A concentrated extract
of maple syrup makes disease-causing bacteria more susceptible to antibiotics,
according to laboratory experiments. The findings suggest that combining maple
syrup extract with common antibiotics could increase the microbes'
susceptibility, leading to lower antibiotic usage.

.............

A concentrated extract of
maple syrup makes disease-causing bacteria more susceptible to antibiotics,
according to laboratory experiments by researchers at McGill University.

The findings, which will be published in the journalApplied and
Environmental Microbiology, suggest that combining maple syrup extract with
common antibiotics could increase the microbes' susceptibility, leading to
lower antibiotic usage. Overuse of antibiotics fuels the emergence of
drug-resistant bacteria, which has become a major public-health concern
worldwide.

Prof. Nathalie Tufenkji's research team in McGill's Department of Chemical
Engineering prepared a concentrated extract of maple syrup that consists mainly
of phenolic compounds. Maple syrup, made by concentrating the sap from North
American maple trees, is a rich source of phenolic compounds.

The researchers tested the extract's effect in the laboratory on
infection-causing strains of certain bacteria, including E. coli and Proteus
mirabilis (a common cause of urinary tract infection). By itself, the extract
was mildly effective in combating bacteria. But the maple syrup extract was
particularly effective when applied in combination with antibiotics. The
extract also acted synergistically with antibiotics in destroying resistant
communities of bacteria known as biofilms, which are common in
difficult-to-treat infections, such as catheter-associated urinary tract
infections.

"We would have to do in vivo tests, and eventually clinical trials,
before we can say what the effect would be in humans," Tufenkji says.
"But the findings suggest a potentially simple and effective approach for
reducing antibiotic usage. I could see maple syrup extract being incorporated
eventually, for example, into the capsules of antibiotics."

The scientists also found that the extract affects the gene expression of
the bacteria, by repressing a number of genes linked with antibiotic resistance
and virulence.

All maple syrup samples used in the study were purchased at local markets
in Montreal, then frozen until the beginning of each experiment, which involved
a series of steps to produce the phenolic-rich extract.

Tufenkji, who holds the Canada Research Chair in Biocolloids and Surfaces,
has also studied the potential for cranberry derivatives to fight
infection-causing bacteria.







Story Source:

The above story is based on materials provided by McGill University. Note: Materials may be edited
for content and length.







Journal Reference:

1.    Vimal B. Maisuria, Zeinab Hosseinidoust,
Nathalie Tufenkji. Polyphenolic Extract from Maple Syrup Potentiates
Antibiotic Susceptibility and Reduces Biofilm Formation of Pathogenic Bacteria. Applied
and Environmental Microbiology, 2015; AEM.00239-15 DOI: 10.1128/AEM.00239-15

http://www.sciencedaily.com/releases/2015/04/150416132632.htm

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